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Date:         Mon, 8 Dec 2003 15:44:16 +0100
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Sender:       Confocal Microscopy List <[log in to unmask]>
From:         Peter Van Osta <[log in to unmask]>
Organization: Union Biometrica N.V. E.S.O.
Subject:      [Fwd: Re: [Microscopy] Re:   A Human Cytome Project ?]
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Search the CONFOCAL archive at http://listserv.acsu.buffalo.edu/cgi-bin/wa?S1=confocal Message forwarded for Guenter K.Valet: Hi, in view of the obvious facts that: 1. the DNA-sequence and functional knowledge on all biomolecules will not permit the assembly of living cell from their components 2. the analysis of organ tissue or biopsy specimens by advanced array technologies typically provides averaged result for many cells but does not address the discrete reactivity of specific cell populations being decisevely important for particular organ or organismic functions it seems important and promising to address molecular principles of cell arrangement and interaction in a human cytome project. Such a project could bundle advanced microscopy, image analysis and other multiparameter cytometric techniques as well as single cell or specific cell group oriented functional genomics arraying and include multidimensional bioinformatics. The goal of the project would be to systematically explore multilevel molecular interrelations within cytomes as they occur in complex diseases like cancers, leukemias, cardiovascular disease, diabetes or in the susceptibility to infection including the detailed search for new pharmacological access points. Best regards G.Valet ****************************************************************** Prof.Dr.Guenter K.Valet Max-Planck-Institut fuer Biochemie Cell Biochemistry Am Klopferspitz 18a D-82152 Martinsried Germany Tel: +49/89/8578-2518, -2525, Fax: +49/89/8578-2563 E-mail: [log in to unmask] Internet: http://www.biochem.mpg.de/valet/cellbio.html ****************************************************************** At 10:14 04.12.03 +0100, Peter Van Osta wrote: >Hi, > >Here are some links to websites with information about Cytomics, this >will provide you with some information and background about what I mean >with a "Human Cytome Project" (see below in this email). > >I got the idea about using massive parallel "readers" on a >"high-throughput" backbone for Cytomics while I visited the Sanger >Center a few years ago where I saw a huge room "buzzing" with >DNA-sequencing machines. > >I wanted to design and develop a cell-screening system, based on a >microscopy-based reader which could do for Cytomics what DNA-sequencing >machines did for Genomics. > >Websites on Cytomics: > >http://www.cytomics.info/ >http://www.biochem.mpg.de/valet/cytomics.html >http://www.biochem.mpg.de/valet/cellpot.html >http://www.ipd.anl.gov/biotech/programs/func-genomics/ > >Best regards, > >Peter Van Osta > >( http://ourworld.compuserve.com/homepages/pvosta/cvwww.htm ) > > -- Met vriendelijke groet, Best regards, Peter Van Osta Union Biometrica N.V./S.A. European Scientific Operations (ESO) Cipalstraat 3 B-2440 Geel Belgium Tel.: +32 (0)14 570 620 Fax.: +32 (0)14 570 621 http://www.unionbio-eu.com/ http://ourworld.compuserve.com/homepages/pvosta/cvwww.htm


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