- Flow cytometry data analysis aims often only at the determination
of cell frequency within one or several multidimensional gates.
An essential part of potentially useful information like
fluorescence intensities, average fluorescence surface densities,
intercolour fluorescence ratios, coefficients of variation of the
fluorescence, light scatter intensity or scatter and fluorescence
ratio distributions of cell populations remain usually
- The goal of data pattern classification in cytomics (cell systems research)
aims at the exhaustive knowledge extraction from flow cytometric or
other multiparameter data by the determination of the most discriminatory
data patterns for individualized disease course predictions or diagnostics.
- CLASSIF1 algorithmic data sieving permits the development
of standardized, instrument and laboratory independent
data pattern classifiers from flow cytometric list mode, flow bead array,
cDNA or protein expression chip array (Lymphochip, Affymetrix),
clinical chemistry, biomedical or clinical data for
or for diagnostic purposes
medical and clinical cytomics)
- the CLASSIF1 algorithm provides access to
with >95% correct disease
course prediction in individual patients as well as to
standardized diagnostic classifications.
- the CLASSIF1 approach facilitates the elaboration of
interlaboratory consensus classifiers in complex
multiparameter data sieving or data mining analysis.
- as a practical consequence, diseases
can be classified at institutions where no sufficient learning sets can
be generated in reasonable times or where costly investigations are
necessary to establish appropriate learning sets.
- furthermore the molecular and biochemical properties of
many body cell systems during disease can be compared
by standardized classification e.g. blood leukocytes versus
tissue or effusion leukocytes.
the self unpacking file containing the Cell Biochemistry pages,
follow the instructions (PC) to
access text and graphics on your harddisk by the Internet browser
free of network delays.
MAC users download and unpack the file on a PC and transfer
the unpacked files to the MAC computer for inspection by the